【Chinese Name】 苦参碱
【English Name】 Matrine (Sophora Alkaloid)
【Synonyms】 α-Matrine, Mother Chrysanthemum Alkaloid
【CAS No】 519-02-8
【Molecular Formula】 C₁₅H₂₄N₂O
【Molecular Weight】 248.36 g/mol
【Plant Source】 Dried roots of Sophora flavescens Ait. (Fabaceae)
【Purity】 ≥98% (HPLC)

Physicochemical Properties

【Appearance】 White crystalline powder
【Solubility】
✓ Freely soluble in: Ethanol, Chloroform, Toluene, Benzene
✓ Soluble in: Acetone, Water (hot)
✓ Slightly soluble in: Petroleum ether
【Melting Point】 76-78°C
【Optical Rotation】 +38° (c=2, EtOH)

Quality Standards

✓ Heavy Metals: <10ppm total
✓ Residual Solvents: Meets ICH Q3C
✓ Microbial Limits: Complies with USP <61>
✓ Related Alkaloids: Oxymatrine <1.5%

Packaging & Storage

【Packaging】
• Standard: 25kg fiber drums with inner PE bags
• Customized packaging available
【Storage】
• 15-25°C in airtight containers
• Protect from light and moisture
• Do not freeze
【Shelf Life】 24 months

Pharmacological Activities

Anticancer Effects:

• Induces apoptosis in HepG2 cells      (IC50 0.5mg/ml)

• Inhibits NF-κB signaling pathway

Antiviral Activity:

• Against HBV (EC50 12μM)

• Reduces HSV-2 replication

Dermatological Use:

• 5% topical formulation for eczema

• Inhibits      IL-4/IL-13 in atopic dermatitis

Safety Data

• LD50 (oral, rat): 2370 mg/kg
• Non-mutagenic (Ames test)
• Skin irritation: Mild (rabbit test)