【英文名称】Levodopa

Technical Specifications

【Chinese Name】 左旋多巴

【English Name】 Levodopa (L-3,4-dihydroxyphenylalanine)

【Chemical Name】 (S)-2-Amino-3-(3,4-dihydroxyphenyl)propanoic acid

【CAS No】 59-92-7

【Molecular Formula】 C₉H₁₁NO₄

【Molecular Weight】 197.19 g/mol

【Purity】 ≥99% (HPLC)

Physicochemical Properties

【Appearance】 White to off-white crystalline powder

【Solubility】

✓ Slightly soluble in water (1:400)

✓ Very slightly soluble in ethanol (1:6000)

✓ Insoluble in ether, chloroform

【Melting Point】 276-278°C (dec.)

【Optical Rotation】 -12.0° to -13.5° (c=5, 1N HCl)

Quality Standards

✓ Heavy Metals: ≤10ppm

✓ Related Substances:

Tyrosine ≤0.5%

Dopamine ≤0.1%

✓ Loss on Drying: ≤0.5%

✓ Residue on Ignition: ≤0.1%

Packaging & Storage

【Packaging】

• Standard: 25kg fiber drum with double PE liners

• Custom sizes: 1kg, 5kg available

【Storage】

• 2-8°C for long-term storage

• Short-term: ≤25°C (desiccated)

• Protect from light and oxygen

Pharmacological Properties

Neurotransmitter Precursor:

Crosses blood-brain barrier via LAT1 transporter

Converts to dopamine by aromatic L-amino acid decarboxylase

Clinical Applications:

• Gold standard for Parkinson's disease therapy

• Restores motor function in 75% of patients

• Onset: 30-60 minutes (oral administration)

Safety Data

• LD50 (oral, rat): 1500 mg/kg

• Pregnancy Category C (US FDA)

• ADRs: Nausea (80%), dyskinesia (50%)